Engrailed controls epaxial-hypaxial muscle innervation and the establishment of vertebrate three-dimensional mobility.
Identifieur interne : 000D27 ( Main/Exploration ); précédent : 000D26; suivant : 000D28Engrailed controls epaxial-hypaxial muscle innervation and the establishment of vertebrate three-dimensional mobility.
Auteurs : Mohi U. Ahmed [Royaume-Uni] ; Ashish K. Maurya ; Louise Cheng [Australie] ; Erika C. Jorge [Brésil] ; Frank R. Schubert [Royaume-Uni] ; Pascal Maire [France] ; M Albert Basson [Royaume-Uni] ; Philip W. Ingham [Singapour] ; Susanne Dietrich [Royaume-Uni]Source :
- Developmental biology [ 1095-564X ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Animaux nouveau-nés, Axones (métabolisme), Danio zébré (embryologie), Danio zébré (métabolisme), Développement musculaire (génétique), Facteurs de transcription (métabolisme), Marqueurs biologiques (métabolisme), Mouvement, Muscles squelettiques (innervation), Muscles squelettiques (métabolisme), Myoblastes (cytologie), Myoblastes (métabolisme), Phénotype, Plan d'organisation du corps (génétique), Poulets (métabolisme), Protéines à homéodomaine (métabolisme), Régulation de l'expression des gènes au cours du développement, Somites (métabolisme), Souris.
- MESH :
- cytologie : Myoblastes.
- embryologie : Danio zébré.
- génétique : Développement musculaire, Plan d'organisation du corps.
- métabolisme : Axones, Danio zébré, Facteurs de transcription, Marqueurs biologiques, Muscles squelettiques, Myoblastes, Poulets, Protéines à homéodomaine, Somites.
- Animaux, Animaux nouveau-nés, Mouvement, Phénotype, Régulation de l'expression des gènes au cours du développement, Souris.
English descriptors
- KwdEn :
- Animals, Animals, Newborn, Axons (metabolism), Biomarkers (metabolism), Body Patterning (genetics), Chickens (metabolism), Gene Expression Regulation, Developmental, Homeodomain Proteins (metabolism), Mice, Movement, Muscle Development (genetics), Muscle, Skeletal (innervation), Muscle, Skeletal (metabolism), Myoblasts (cytology), Myoblasts (metabolism), Phenotype, Somites (metabolism), Transcription Factors (metabolism), Zebrafish (embryology), Zebrafish (metabolism).
- MESH :
- chemical , metabolism : Biomarkers, Homeodomain Proteins, Transcription Factors.
- cytology : Myoblasts.
- embryology : Zebrafish.
- genetics : Body Patterning, Muscle Development.
- innervation : Muscle, Skeletal.
- metabolism : Axons, Chickens, Muscle, Skeletal, Myoblasts, Somites, Zebrafish.
- Animals, Animals, Newborn, Gene Expression Regulation, Developmental, Mice, Movement, Phenotype.
Abstract
Chordates are characterised by contractile muscle on either side of the body that promotes movement by side-to-side undulation. In the lineage leading to modern jawed vertebrates (crown group gnathostomes), this system was refined: body muscle became segregated into distinct dorsal (epaxial) and ventral (hypaxial) components that are separately innervated by the medial and hypaxial motors column, respectively, via the dorsal and ventral ramus of the spinal nerves. This allows full three-dimensional mobility, which in turn was a key factor in their evolutionary success. How the new gnathostome system is established during embryogenesis and how it may have evolved in the ancestors of modern vertebrates is not known. Vertebrate Engrailed genes have a peculiar expression pattern as they temporarily demarcate a central domain of the developing musculature at the epaxial-hypaxial boundary. Moreover, they are the only genes known with this particular expression pattern. The aim of this study was to investigate whether Engrailed genes control epaxial-hypaxial muscle development and innervation. Investigating chick, mouse and zebrafish as major gnathostome model organisms, we found that the Engrailed expression domain was associated with the establishment of the epaxial-hypaxial boundary of muscle in all three species. Moreover, the outgrowing epaxial and hypaxial nerves orientated themselves with respect to this Engrailed domain. In the chicken, loss and gain of Engrailed function changed epaxial-hypaxial somite patterning. Importantly, in all animals studied, loss and gain of Engrailed function severely disrupted the pathfinding of the spinal motor axons, suggesting that Engrailed plays an evolutionarily conserved role in the separate innervation of vertebrate epaxial-hypaxial muscle.
DOI: 10.1016/j.ydbio.2017.08.011
PubMed: 28807781
Affiliations:
- Australie, Brésil, France, Royaume-Uni, Singapour
- Île-de-France
- Paris
- Université nationale de Singapour
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Le document en format XML
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Electronic address: susanne.dietrich@port.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>King's College London, Dept. of Craniofacial Development and Stem Cell Biology, Floor 27, Guy's Hospital Tower Wing, London SE1 9RT, UK; Institute of Biomedical and Biomolecular Science, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT</wicri:regionArea><wicri:noRegion>Portsmouth PO1 2DT</wicri:noRegion></affiliation></author></analytic><series><title level="j">Developmental biology</title><idno type="eISSN">1095-564X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Animals, Newborn</term><term>Axons (metabolism)</term><term>Biomarkers (metabolism)</term><term>Body Patterning (genetics)</term><term>Chickens (metabolism)</term><term>Gene Expression Regulation, Developmental</term><term>Homeodomain Proteins (metabolism)</term><term>Mice</term><term>Movement</term><term>Muscle Development (genetics)</term><term>Muscle, Skeletal (innervation)</term><term>Muscle, Skeletal (metabolism)</term><term>Myoblasts (cytology)</term><term>Myoblasts (metabolism)</term><term>Phenotype</term><term>Somites (metabolism)</term><term>Transcription Factors (metabolism)</term><term>Zebrafish (embryology)</term><term>Zebrafish (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Animaux nouveau-nés</term><term>Axones (métabolisme)</term><term>Danio zébré (embryologie)</term><term>Danio zébré (métabolisme)</term><term>Développement musculaire (génétique)</term><term>Facteurs de transcription (métabolisme)</term><term>Marqueurs biologiques (métabolisme)</term><term>Mouvement</term><term>Muscles squelettiques (innervation)</term><term>Muscles squelettiques (métabolisme)</term><term>Myoblastes (cytologie)</term><term>Myoblastes (métabolisme)</term><term>Phénotype</term><term>Plan d'organisation du corps (génétique)</term><term>Poulets (métabolisme)</term><term>Protéines à homéodomaine (métabolisme)</term><term>Régulation de l'expression des gènes au cours du développement</term><term>Somites (métabolisme)</term><term>Souris</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term><term>Homeodomain Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Myoblastes</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Myoblasts</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Danio zébré</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Zebrafish</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Body Patterning</term><term>Muscle Development</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Développement musculaire</term><term>Plan d'organisation du corps</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Axons</term><term>Chickens</term><term>Muscle, Skeletal</term><term>Myoblasts</term><term>Somites</term><term>Zebrafish</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Axones</term><term>Danio zébré</term><term>Facteurs de transcription</term><term>Marqueurs biologiques</term><term>Muscles squelettiques</term><term>Myoblastes</term><term>Poulets</term><term>Protéines à homéodomaine</term><term>Somites</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Animals, Newborn</term><term>Gene Expression Regulation, Developmental</term><term>Mice</term><term>Movement</term><term>Phenotype</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Animaux nouveau-nés</term><term>Mouvement</term><term>Phénotype</term><term>Régulation de l'expression des gènes au cours du développement</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chordates are characterised by contractile muscle on either side of the body that promotes movement by side-to-side undulation. In the lineage leading to modern jawed vertebrates (crown group gnathostomes), this system was refined: body muscle became segregated into distinct dorsal (epaxial) and ventral (hypaxial) components that are separately innervated by the medial and hypaxial motors column, respectively, via the dorsal and ventral ramus of the spinal nerves. This allows full three-dimensional mobility, which in turn was a key factor in their evolutionary success. How the new gnathostome system is established during embryogenesis and how it may have evolved in the ancestors of modern vertebrates is not known. Vertebrate Engrailed genes have a peculiar expression pattern as they temporarily demarcate a central domain of the developing musculature at the epaxial-hypaxial boundary. Moreover, they are the only genes known with this particular expression pattern. The aim of this study was to investigate whether Engrailed genes control epaxial-hypaxial muscle development and innervation. Investigating chick, mouse and zebrafish as major gnathostome model organisms, we found that the Engrailed expression domain was associated with the establishment of the epaxial-hypaxial boundary of muscle in all three species. Moreover, the outgrowing epaxial and hypaxial nerves orientated themselves with respect to this Engrailed domain. In the chicken, loss and gain of Engrailed function changed epaxial-hypaxial somite patterning. Importantly, in all animals studied, loss and gain of Engrailed function severely disrupted the pathfinding of the spinal motor axons, suggesting that Engrailed plays an evolutionarily conserved role in the separate innervation of vertebrate epaxial-hypaxial muscle.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Brésil</li><li>France</li><li>Royaume-Uni</li><li>Singapour</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Université nationale de Singapour</li></orgName></list><tree><noCountry><name sortKey="Maurya, Ashish K" sort="Maurya, Ashish K" uniqKey="Maurya A" first="Ashish K" last="Maurya">Ashish K. Maurya</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Ahmed, Mohi U" sort="Ahmed, Mohi U" uniqKey="Ahmed M" first="Mohi U" last="Ahmed">Mohi U. Ahmed</name></noRegion><name sortKey="Basson, M Albert" sort="Basson, M Albert" uniqKey="Basson M" first="M Albert" last="Basson">M Albert Basson</name><name sortKey="Dietrich, Susanne" sort="Dietrich, Susanne" uniqKey="Dietrich S" first="Susanne" last="Dietrich">Susanne Dietrich</name><name sortKey="Schubert, Frank R" sort="Schubert, Frank R" uniqKey="Schubert F" first="Frank R" last="Schubert">Frank R. Schubert</name></country><country name="Australie"><noRegion><name sortKey="Cheng, Louise" sort="Cheng, Louise" uniqKey="Cheng L" first="Louise" last="Cheng">Louise Cheng</name></noRegion></country><country name="Brésil"><noRegion><name sortKey="Jorge, Erika C" sort="Jorge, Erika C" uniqKey="Jorge E" first="Erika C" last="Jorge">Erika C. Jorge</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Maire, Pascal" sort="Maire, Pascal" uniqKey="Maire P" first="Pascal" last="Maire">Pascal Maire</name></region></country><country name="Singapour"><noRegion><name sortKey="Ingham, Philip W" sort="Ingham, Philip W" uniqKey="Ingham P" first="Philip W" last="Ingham">Philip W. Ingham</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28807781" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |